Tablets, two-piece capsules and a clear softgel resting on a white surface
Photo: Pixabay / Pexels

Tablet vs capsule sounds like a question about which one works better, but for someone holding a single loose pill it is usually a more basic question: what kind of thing is this? The answer matters because the two forms are built differently, look different up close, and carry their identifying marks in different places. Knowing which one you have is the first step in narrowing down what it is.

A tablet is a solid usually made by pressing powdered ingredients together into a shape, often round, oval or oblong. A capsule is a shell, hard or soft, that holds the medicine inside it. Hard capsules come in two fitted halves; soft capsules, often called softgels, are one sealed piece. A caplet is a tablet pressed into a capsule shape.

Tablet vs capsule: the definitions behind the label

The words on a drug label are not casual descriptions. FDA uses a fixed list of dosage-form terms in the structured labeling that manufacturers submit, and terms such as TABLET, CAPSULE, TABLET, FILM COATED and CAPSULE, LIQUID FILLED all appear on it. The definitions behind those terms come from the NCI Thesaurus, a reference vocabulary maintained by the National Cancer Institute.

The NCI Thesaurus describes a tablet as ingredients “pressed or compacted together, usually in the form of a relatively flat and round, square or oval shape.” Under any coating, an ordinary tablet is solid rather than a shell with a fill.

A capsule, in the definition the same entry carries from the CDISC standards vocabulary, holds its contents “within either a hard or soft soluble container or shell,” and that shell is “made of a suitable form of gelatin or other substance.” The “other substance” is worth noting: not every capsule shell is gelatin, so the material alone is not a reliable way to tell one product from another.

The three kinds you are most likely to be holding

Most loose pills found in a home fall into one of three physical types, and each has a tell you can see without any equipment.

A tablet. Solid, usually matte or lightly glossy if coated, and the same material all the way through if it is ever broken. Tablets can be round, oval, oblong, square or shaped more unusually. Some have a line pressed across one face, which is a score.

A hard capsule. The NCI Thesaurus describes the hard shell as “two parts, a body and cap.” Look along the length of the capsule and you can usually see where the shorter cap slides over the longer body. The two halves are often different colors, which is one of the most useful features for identification. Some hard capsules have a thin ring around the join. That ring is a band: in the NCI definition of a gelatin-coated capsule, a “banding process” adds extra layers of gelatin “so as to form a complete seal.”

A softgel. A softgel is described as “a one-piece, hermetically sealed soft gelatin casing” with a liquid, suspension or semisolid fill inside. There is no cap and no join, only a smooth, slightly flexible shell. Some softgels are clear enough that you can see the liquid inside.

What a caplet actually is

“Caplet” is one of the most misunderstood words in this area. It is often mistaken for a coated capsule or a separate kind of medicine. The NCI Thesaurus definition is simpler: a caplet is a dosage form in which “a tablet has been compacted into capsule shape.” It is a tablet. It is solid all the way through, it has no cap and body, and it cannot be opened.

That distinction trips up shape searches, because a caplet ends up described as oval or capsule shaped, depending on the labeler. The details of how shape words are assigned, and why the same tablet can be listed two different ways, are in pill shapes and names.

Where the imprint is on each one

Federal rules treat tablets and capsules the same way when it comes to identification. Under 21 CFR 206.10, a solid oral drug product must be “clearly marked or imprinted with a code imprint” that, together with its size, shape and color, permits it to be uniquely identified. Part 206 defines solid oral dosage forms as “capsules, tablets, or similar drug products intended for oral use,” and the rule applies to prescription and over-the-counter products.

“Imprinted” covers several methods. The regulation lists “embossing, debossing, engraving, or printing with ink.” That matters when you are looking for the code:

  • On a tablet, the code is often pressed into the surface (debossed) or printed in ink on a coating. Check both faces and the edge.
  • On a hard capsule, the code is usually printed in ink on the shell, sometimes on the cap, sometimes on the body, sometimes on both. Rotate the capsule all the way round before deciding there is nothing there.
  • On a softgel, the code is printed on the shell and can be faint, especially on a translucent capsule. Tilting it under a light helps.

There are exceptions. Part 206 exempts certain categories of products, and FDA can also exempt a product when its “size, shape, texture, or other physical characteristics make imprinting technologically infeasible or impossible,” so some legitimate products carry no code. How to read the code once you find it is covered in the pill imprint codes guide.

What shape and color can and cannot tell you

Knowing the form narrows a search, but it does not finish it. Two different medicines can come as white oval tablets of almost the same size, and the same medicine can come as a tablet from one manufacturer and a capsule from another. Color varies too, because inactive ingredients differ between manufacturers. That is why identifying a pill by color and shape only gets you to a shortlist, and the imprint is what decides it.

A practical order of checks for a loose pill:

  1. Decide the form. Solid all through (tablet or caplet), two fitted halves (hard capsule), or one sealed shell (softgel).
  2. Find the imprint. Both faces of a tablet, all the way round a capsule.
  3. Note the colors exactly. For a two-tone capsule, note which color is the cap and which is the body.
  4. Measure if you can. Length in millimeters narrows a shortlist quickly.

The “which is better” question

Claims that one form is always absorbed faster, lasts longer or is gentler than the other do not hold as a general rule, because the answer depends on the specific product and how it was designed. A medicine is made as a tablet or a capsule for reasons that belong to that product: how the ingredient behaves, how it should be released, what makes it stable.

Some capsules and tablets are also built so that the shell or coating controls when the medicine is released, which is why some are designed not to be opened or crushed, as explained in the do not crush list.

When you are still not sure

If you have looked at a pill carefully and still cannot tell whether it is a tablet or a capsule, or the imprint is worn, take it to a pharmacist along with any bottles it might have come from. The pharmacist is the right person to confirm what it is, and to answer any question about whether a different form of a medicine exists or would suit the person taking it. A clear photo of both sides, taken in good light, is also the best starting point for identifying a pill by picture.

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